Famous Clinical Trials in History
Famous Clinical Trials In History is a structured science dataset with 16 entries. Its fields include Trial, Lead Investigator, Year. The source values are preserved as a structured reference table.
Every row is shown below and is also available as CSV, JSON, or Excel.
Dataset details
- Table scope
- All 16 rows
- Fields
- 6 columns
- Source
- Community curated
- Data updated
- Apr 9, 2026
Included fields: Trial, Lead Investigator, Year, Disease, Participants, and 1 more.
The table contains every record in this dataset; the same records are available in each download format.
Preview observations
- Year span
- 1948 to 2020
- Across 16 preview rows
- Participants range
- 107 to 1,800,000
- Across 16 preview rows
Useful for
- Comparing Trial, Lead Investigator, and Year across science entries
- Building reference tables, charts, or analyses from 16 downloadable records
Trial↕ | Lead Investigator↕ | Year↕ | Disease↕ | Participants↕ | Outcome↕ |
|---|---|---|---|---|---|
Salk Polio Vaccine Trial | Jonas Salk, Thomas Francis | 1954 | Polio | 1,800,000 | Largest field trial in history; vaccine 80-90% effective; near eradication of polio |
MRC Streptomycin Trial | Austin Bradford Hill | 1948 | Tuberculosis | 107 | First randomized controlled trial; established RCT as gold standard |
RECOVERY Trial | Peter Horby, Martin Landray | 2020 | COVID-19 | 47,000 | Showed dexamethasone cuts deaths in ventilated patients by one-third |
Framingham Heart Study | Thomas Royle Dawber | 1948 | Cardiovascular Disease | 5,209 | Identified cholesterol, blood pressure and smoking as CV risk factors; ongoing |
Women's Health Initiative | Bernadine Healy, NIH | 1991 | Cancer, Heart Disease, Osteoporosis | 161,808 | Showed hormone replacement therapy increases breast cancer and stroke risk |
ISIS-2 Trial | Rory Collins et al. | 1988 | Acute Myocardial Infarction | 17,187 | Aspirin and streptokinase each cut mortality; combined cut deaths by 42% |
4S (Simvastatin Study) | Scandinavian group | 1994 | Coronary Heart Disease | 4,444 | First trial to show statins reduce mortality in high-risk patients |
GISSI-1 | Italian GISSI Group | 1986 | Myocardial Infarction | 11,806 | Thrombolysis with streptokinase cut hospital mortality significantly |
UKPDS (Diabetes) | Robert Turner, Oxford | 1977 | Type 2 Diabetes | 5,102 | Intensive glucose control reduces microvascular complications; 20-year follow-up |
Physicians' Health Study | Charles Hennekens | 1982 | Cardiovascular Disease, Cancer | 22,071 | Aspirin cut first MI risk by 44%; reshaped primary prevention |
HOPE Trial | Salim Yusuf | 2000 | Cardiovascular Disease | 9,297 | Ramipril reduced CV events in patients without heart failure |
BCG Tuberculosis Trial (India) | Indian Council of Medical Research | 1968 | Tuberculosis | 366,625 | Showed BCG vaccine had little protective effect in South India |
AZT for HIV (ACTG 076) | Edward Connor et al. | 1994 | HIV | 477 | AZT cut mother-to-child HIV transmission by 67% |
Pfizer-BioNTech COVID Vaccine Trial | Kathrin Jansen, Ugur Sahin | 2020 | COVID-19 | 43,548 | 95% efficacy; first mRNA vaccine authorized for human use |
MRFIT Trial | National Heart, Lung and Blood Institute | 1973 | Coronary Heart Disease | 12,866 | Multifactor risk intervention showed modest benefit; reshaped CV prevention |
CAPRIE Trial | Mark Gent | 1996 | Atherothrombosis | 19,185 | Clopidogrel modestly better than aspirin in preventing vascular events |
Free to explore · No signup needed
Related Datasets
More in Science
Periodic Table Elements
All 118 chemical elements of the periodic table with symbols, categories, discoverers, and what each element is known for.
Controversial Medical Experiments
Tuskegee syphilis, Stanford prison, Milgram's shocks or Unit 731 - which ethical horror story from medical history is the most shocking?
Famous Extreme Weather Events in History
The 1816 Year Without a Summer, the Tri-State Tornado, the 1900 Galveston Hurricane — which weather event left the deepest mark on human history?
Scientific Breakthroughs
Transformative scientific discoveries that reshaped our understanding of the world, from heliocentrism to CRISPR gene editing.
Natural Disasters
Devastating natural disasters throughout history including earthquakes, tsunamis, volcanic eruptions, cyclones, and floods with their human toll.
Nobel Prize in Medicine Winners
All Nobel Prize in Physiology or Medicine laureates.