People

Renaissance Popes

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Updated:4/9/2026
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Pope
Birth Name
Papacy
Family
Known For
Nicholas V
Tommaso Parentucelli1447-1455ParentucelliFounded Vatican Library, first Renaissance pope, patron of humanists
Callixtus III
Alfonso de Borja1455-1458BorgiaFirst Borgia pope, rehabilitated Joan of Arc, launched crusade against Ottomans
Pius II
Enea Silvio Piccolomini1458-1464PiccolominiHumanist poet, wrote autobiography Commentaries, tried to launch crusade
Paul II
Pietro Barbo1464-1471BarboVenetian nephew of Eugene IV, built Palazzo Venezia, loved carnival games
Sixtus IV
Francesco della Rovere1471-1484della RovereBuilt the Sistine Chapel, Pazzi conspiracy against Medici, massive nepotism
Innocent VIII
Giovanni Battista Cybo1484-1492CyboIssued witch-hunting bull Summis desiderantes, openly acknowledged children
Alexander VI
Rodrigo Borgia1492-1503BorgiaMost infamous pope, fathered Cesare and Lucrezia, divided New World between Spain and Portugal
Pius III
Francesco Todeschini Piccolomini1503PiccolominiPope for 26 days, nephew of Pius II, died of gout
Julius II
Giuliano della Rovere1503-1513della RovereWarrior Pope, commissioned Sistine ceiling from Michelangelo and St Peter's from Bramante
Leo X
Giovanni de' Medici1513-1521MediciSon of Lorenzo the Magnificent, excommunicated Luther, sold indulgences for St Peter's
Adrian VI
Adriaan Florensz Boeyens1522-1523BoeyensLast non-Italian pope until John Paul II, austere reformer, died within a year
Clement VII
Giulio de' Medici1523-1534MediciSack of Rome 1527 by imperial troops, refused Henry VIII's annulment, lost England
Paul III
Alessandro Farnese1534-1549FarneseConvoked Council of Trent, approved Jesuits, commissioned Michelangelo's Last Judgment
Julius III
Giovanni Maria Ciocchi del Monte1550-1555Ciocchi del MonteScandal over favorite Innocenzo, patron of Palestrina music, built Villa Giulia
Paul IV
Gian Pietro Carafa1555-1559CarafaCounter-Reformation hardliner, created Roman Ghetto, Index of Forbidden Books
Pius IV
Giovanni Angelo Medici1559-1565Medici of MilanClosed Council of Trent, unrelated to Florentine Medici, built Porta Pia

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