Sports

Iconic March Madness Upsets

UMBC over Virginia, Lehigh over Duke, Saint Peter's Cinderella run -- which NCAA tournament upset shook the bracket hardest?

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Updated:4/10/2026

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Matchup↕	Year↕	Round↕	Upset Seed↕	Favorite Seed↕	Score↕	Why It Mattered↕
UMBC over Virginia	2018	First Round	16	1	74-54	First 16-seed to beat a 1-seed in men's tournament history
Lehigh over Duke	2012	First Round	15	2	75-70	C.J. McCollum scored 30 to end Coach K's early exit
Saint Peter's Cinderella Run	2022	Elite Eight	15	3	67-64 vs Purdue	First 15-seed to reach Elite Eight, beat Kentucky and Murray State en route
Florida Gulf Coast over Georgetown	2013	Second Round	15	2	78-68	Dunk City became a sensation, first 15-seed to reach Sweet 16
NC State 1983 Title Run	1983	Championship	6	1	54-52 vs Houston	Jim Valvano's miracle, Lorenzo Charles dunk at the buzzer
Villanova over Georgetown	1985	Championship	8	1	66-64	Shot 78.6% from the field in a near-perfect upset of Patrick Ewing's Hoyas
Norfolk State over Missouri	2012	First Round	15	2	86-84	Norfolk State hit clutch free throws to complete the stunner
Middle Tennessee over Michigan State	2016	First Round	15	2	90-81	Blue Raiders dominated from start to finish against Izzo's Spartans
Loyola Chicago 2018 Run	2018	Final Four	11	1	69-68 vs Tennessee	Sister Jean's team reached Final Four with four straight nail-biters
Hampton over Iowa State	2001	First Round	15	2	58-57	Hampton's 1-point win stunned the Big 12 champs
Oral Roberts 2021 Run	2021	Sweet Sixteen	15	2	81-78 vs Ohio State	Max Abmas led the Golden Eagles past Ohio State and Florida
Chaminade over Virginia	1982	Non-tournament	0	0	77-72	NAIA school beat the No. 1 ranked team in the country, greatest upset in college basketball history
Richmond over Syracuse	1991	First Round	15	2	73-69	One of the earliest 15-over-2 upsets in tournament history
Coppin State over South Carolina	1997	First Round	15	2	78-65	Larry Stewart's Eagles blew out the Gamecocks
George Mason to Final Four	2006	Final Four	11	1	86-84 OT vs UConn	Patriots beat Michigan State, UNC, and UConn to reach Final Four as mid-major